Réseau moléculaire de molécules antifongiques de co-produits de la vigne
Tardif et al. 2024

Antifungal Metabolites from Grapevine Byproducts Using Bioactivity-Based Molecular Networkings.

A New article from the research project StilDeTox published in Journal of Agricultural and Food Chemistry

Tardif C., Rouger C., Miranda J., Ahmed O.S., Richard-Forget F., Atanasova V., Waffo-Teguo P. (2024). Targeting of antifungal metabolites from grapevine byproducts by UPLC–HRMS/MS approaches using bioactivity-based molecular networking. Journal of Agricultural and Food Chemistryhttps://doi.org/10.1021/acs.jafc.3c09531

The article is from a collaboration with UMR 1366 (OENO, ISVV)

ABSTRACT: This study focuses on countering Fusarium graminearum, a harmful fungal pathogen impacting cereal crops and human health through mycotoxin production. These mycotoxins, categorized as type B trichothecenes, pose significant health risks.

Research explores natural alternatives to synthetic fungicides, particularly investigating phenolics in grapevine byproducts. Thirteen eco-extracts from five French grape varieties (Merlot, Cabernet Sauvignon, Sauvignon blanc, Tannat, and Artaban) exhibited substantial antifungal properties, with ten extracts displaying remarkable effects. Extracts from grapevine stems and roots notably reduced fungal growth by over 91% after five days. Through UHPLC−HRMS/MS analysis and metabolomics, the study identified potent antifungal compounds such as ampelopsin A and cyphostemmin B, among other oligomeric stilbenes. Interestingly, this approach showed that flavan-3-ols have been identified as markers for extracts that induce fungal growth. Root extracts from rootstocks, rich in oligostilbenes, demonstrated the highest antifungal activity. This research underscores grapevine byproducts’ potential both as a sustainable approach to control F. graminearum and mycotoxin contamination in cereal crops and the presence of different metabolites from the cultivars of grapevine, suggesting different activities.

Modification date: 24 April 2024 | Publication date: 24 April 2024 | By: Communication MycSA